Table 3 Significant SNPs of conditional independent analysis for FLI-defined FLD
Chr | SNP | RA | EA | Function | Gene | BETA | Z score | P | Associated traits* |
|---|---|---|---|---|---|---|---|---|---|
2 | rs6547692 | G | A | intron | GCKR | -0.10 | -8.43 | 3.41 × 10− 17 | LDL-C, TG, TC |
4 | rs13130484 | C | T | intergenic | - | 0.08 | 5.83 | 5.60 × 10− 09 | BMI, WC |
6 | rs3798519 | A | C | intron | TFAP2B | 0.08 | 5.63 | 1.80 × 10− 08 | BMI, T2DM |
7 | rs61010704 | A | G | intron | MLXIPL | -0.14 | -6.70 | 2.03 × 10− 11 | HDL-C |
7 | rs3779273 | G | A | intron | MAGI2 | -0.07 | -5.72 | 1.07 × 10− 08 | BMI |
8 | rs326 | A | G | intron | LPL | -0.08 | -5.57 | 2.62 × 10− 08 | NAFLD |
8 | rs2980888 | T | C | intron | TRIB1AL | -0.09 | -7.31 | 2.69 × 10− 13 | NAFLD |
8 | rs569067863 | G | A | intron | RHPN1 | 1.21 | 5.49 | 4.03 × 10− 08 | Novel |
9 | rs7469554 | A | G | intron | LMX1B | -0.06 | -5.56 | 2.68 × 10− 08 | Novel |
11 | rs662799 | G | A | upstream | ZPR1 | -0.22 | -17.24 | 1.39 × 10− 66 | HDL-C, TG, TC |
16 | rs73537313 | T | G | intron | - | -0.07 | -5.68 | 1.38 × 10− 08 | Novel |
16 | rs7193144 | T | C | intron | FTO | 0.17 | 10.10 | 5.24 × 10− 24 | BMI |
17 | rs6504543 | T | C | intron | BPTF | 0.08 | 6.21 | 5.31 × 10− 10 | Novel |
19 | rs438811 | C | T | upstream | APOC1 | 0.13 | 9.17 | 4.60 × 10− 20 | TG, TC |
19 | rs36040835 | T | G | intron | QPCTL | 0.15 | 6.43 | 1.26 × 10− 10 | Novel |
22 | rs5751901 | T | C | upstream | LRRC75B | 0.11 | 9.11 | 8.16 × 10− 20 | GGT |