The m6A revolution: transforming tumor immunity and enhancing immunotherapy outcomes

Cell & Bioscience

Table 1 The correlation between m6A regulators and immune indexex in cancer tissues

Name	Cancer type	Marker type	Sample size	Prognostic value	Association	Refs.
METTL3	CRC	Protein	167		Positive correlation with CD33 + MDSC infiltration	[101]
METTL3/IGF2BP3	BC	Protein	140		Positive correlation with PD-L1 expression	[112]
METTL14	CRC	mRNA	22		Positive correlation with CD8 + T cell infiltration	[61]
ALKBH5	GBM	Protein	39		Positive correlation with CD68 + TAM infiltration	[102]
ALKBH5	NSCLC	Protein	55		Positive correlation with PD-L1 and TAM infiltration	[103]
ALKBH5	HNSCC	Protein	138		Negative correlation with the RIG-I and IFN-α	[96]
ALKBH5	ICC	Protein	127		Positive correlation with PD-L1 expression	[114]
ALKBH5	CRC	Protein	775	Poor prognosis		[141]
FTO	HCC	mRNA/Protein	95	Poor overall and disease-free survival		[142]
YTHDF1	GC	Protein/mRNA	278/101	Poor survival		[148]
YTHDF1	CRC	Protein	408	Poor survival	Negative correlation with the IFN-γ response pathway and CD8 + T cell infiltration	[104]
YTHDF1	CRC	Protein	200		Negative correlation with CD8 + T cell infiltration	[149]
YTHDF1	Melanoma	Protein	48		Negative correlation with CD8 + T cell infiltration	[122]
YTHDF2	BLCA	Protein	128	Poor overall survival		[97]
YTHDF2	BLCA	Protein	68		Negative correlation with the RIG-I	[97]
IGF2BP1	HCC	Protein	90			[117]

CRC colorectal cancer; MDSC Myeloid-derived suppressor cell; BC breast cancer; GBM glioblastoma; NSCLC non-small-cell lung cancer; HNSCC head and neck squamous cell carcinoma; TAM tumor-associated macrophage; ICC intrahepatic cholangiocarcinoma; HCC hepatocellular carcinoma; GC gastric cancer; BLCA bladder cancer; RIG-I RNA sensor RIG-I

ISSN: 2045-3701